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North West London Pathology > Tests > Heparin Induced Thrombocytopenia (HIT) Antibody Quantitation

Heparin Induced Thrombocytopenia (HIT) Antibody Quantitation

Category Haematology >> Specialised Coagulation Services
Test background

Quantitation of antibodies to the heparin:PF4 (platelet factor 4) complex is performed by chemiluminescent technique. Results greater than a validated cut-off value are suggestive of HIT though all results should be discussed with the haematology clinical team.
Clinical Indications

For investigation into Heparin Induced Thrombocytopenia (HIT)
Reference range

Results >1.00 U/mL are highly suggestive of HIT.

For advice with interpretation please contact the lab or haematology clinical team
Sample & container required Adults - 2.7 ml Sodium citrate; Paediatric – 1.8 ml sodium citrate
Turnaround time 24 hours
Notes
  • Sample requests must be accompanied by a ‘4T’ HIT clinical probability score (available on intranet or from Special Coagulation lab at Hammersmith Hospital).
  • All requests must be discussed with and approved by the haematology clinical team.
  • Please note: samples will be rejected if under/over-filled, clotted or haemolysed.
  • Please note: test only performed during core hours Monday – Friday 9.00-17.00.

Results >1.00 U/mL are highly suggestive of HIT.

For advice with interpretation please contact the lab or haematology clinical team.