|Category||Biochemistry >> Oncology|
Inhibins are heterodimeric polypeptide hormones composed of alpha (α) and beta (β) subunits. The inhibin molecule has a molecular weight of approximately 32-36 kD. They suppress the secretion of pituitary follicle stimulating hormone (FSH) and also have local paracrine actions in the gonads. Inhibins are produced by the sertoli cells of the testis and the granulosa cells of the ovary.
Inhibin B consists of an α-subunit and a β-subunit. Inhibin B is used for the relapse detection in granulosa cell tumour (GCT) of the ovary. Inhibin B measurements have also been reported as markers for the assessment of sertoli cell function and ovarian reserve.
- Assessment of male or female gonadal function
|Sample & container required||SST (gold top) preferred, serum (red top) accepted|
|Sample volume||0.5 mL|
|Transport storage||Store at 2-8°C andsend by first class post. If sample receipt will be delayed by >2 days, store samples at -20°C and send frozen.|
|Turnaround time||4 weeks|
Beckman Coulter ELISA. Higher follicular/ovulatory phase levels are observed in multi-follicular cycles and may indicate PCOS. HRT will artificially stimulate inhibin B production in the menopause.
Haemolysed or lipaemic samples are not suitable for analysis.