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North West London Pathology > Tests > Insulin-like growth factor 1 (IGF1)

Insulin-like growth factor 1 (IGF1)

Category Biochemistry >> Endocrinology
Test background

IGF-1 is a major regulator of cell growth and differentiation. IGF-1 synthesis is subject to growth hormone (GH) control and occurs predominantly in the liver, though many cell types can and do produce IGF-1 to potentiate localised, paracrine effects. Concentrations of IGF-1 directly correlate with those of GH and are diagnostic of GH excess (acromegaly) and deficiency (dwarfism and related pituitary dysfunction, as well as chronic protein malnutrition/malabsorption).
Clinical Indications

Suspected acromegaly Suspected dwarfism or suspected pituitary insufficiency
Reference range
Females Males
Age Lower Limit (nmol/L) Upper Limit (nmol/L) Age Lower Limit (nmol/L) Upper Limit (nmol/L)
<1 16.9 <1 12.9
1-2 21.9 1-2 18.9
3-5 32.9 3-5 29.9
6-8 3.0 52.0 6-8 2.0 45.0
9-11 6.5 72.0 9-11 3.0 60.0
12-15 12.0 78.0 12-15 6.5 68.0
16-20 14.0 68.0 16-20 15.5 67.0
21-30 11.0 46.0 21-30 10.5 47.0
31-40 10.0 38.0 31-40 10.5 32.0
41-50 7.5 35.0 41-50 8.5 31.0
51-60 5.5 32.0 51-60 6.5 30.0
61-70 3.5 32.0 61-70 3.5 32.0
71-80 3.0 30.0 71-80 2.5 32.0
>80 2.0 25.0 >80 2.0 24.0
Sample & container required Serum (red top)
Sample volume 0.5 mL
Transport storage Stable at 2-8°C for 72 hours. Please freeze pending dispatch for analysis. Send to lab frozen.
Turnaround time 1 week
Notes

Grossly haemolysed samples are unsuitable for this assay.