Skip to main content

Please note that this is a beta version of our website. Should you encounter any bugs, glitches, lack of functionality or other problems on the website, please let us know immediately so we can rectify these accordingly. Your help in this regard is greatly appreciated! You can email us.

Login to North West London Pathology – consumables service

If you need a new account or you have a query about your order, please telephone the pathology call centre on 0203 313 5353.

If you have forgotten your password you can reset this yourself. Please click here if you have forgotten your password.

Results Line and Enquiries

0203 313 5353

Lactate:pyruvate ratio in CSF and plasma

Category Biochemistry
Test background

Measurement of plasma lactate may be indicated in children presenting with myopathy or neurological signs. A child with a persistently elevated lactate level, not explained by causes such as hypoxia, poor perfusion/shock, fits or liver disease, should be investigated for inborn metabolic disorders. In neurological disorders, lactic acidosis may be confined to the CNS without systemic acidosis and the measurement of CSF lactate is useful. A relatively low pyruvate with a raised lactate (lactate:pyruvate ratio >25) is suggestive of pyruvate carboxylase deficiency or respiratory chain defects.

Clinicial Indications

A child with a persistently elevated lactate level not explained by causes such as hypoxia, poor perfusion/shock, fits or liver disease.

Reference range

See report

Sample & container required Pyruvate is an unstable intermediate. Samples for lactate:pyruvate ratio must be deproteinised on collection according to the protocol of the referral laboratory.
Sample volume See protocol
Turnaround time Up to 6 weeks
Notes

Not currently performed in house; this is a referred test.
This is a rarely requested test and should not be undertaken without discussion with laboratory clinical staff.