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Macroprolactin

Category Biochemistry >> Endocrinology
Test background

Macroprolactinaemia refers to a polymeric form of prolactin in which several molecules form aggregates with circulating IgG. This rarely elicits a biological response due to the inability of such a large molecule to interact with the prolactin receptor, however, it can be detected by immunoassays leading to spurious elevated prolactin results.

Clinical Indications

Differential diagnosis of macroprolactin-associated hyperprolactinaemia with that of prolactinoma, hypothyroidism or drug/stress-induced hyperprolactinaemia, eg. Assayed prolactin >600 mIU/L (female) or >350mIU/L (male) where physiological or pathological causes of hyperprolactinaemia are excluded

Reference range

See report

Sample & container required SST (gold top) or serum (red top)
Sample volume 0.5 mL
Transport storage Stable at 2-8°C for 72 hours. Please freeze pending dispatch for analysis. Sample can be sent by first class post.
Turnaround time 10 days