Manganese
| Category | Biochemistry >> Trace elements |
|---|---|
| Test background |
Manganese is a trace element that is an essential co-factor for several enzymes, including manganese superoxide dismutase, pyruvate carboxylase and isocitrate dehydrogenase. Manganese is typically measured to assess risk of toxicity due to industrial exposure or over-supplementation of Mn in patients on TPN. The symptoms of toxicity are largely neurological and are similar to Parkinson’s disease. Patients with Behçet disease, a form of chronic systemic vasculitis, also exhibit increased blood manganese, and it is suggested that increased activity of superoxide dismutase may contribute to the pathogenesis of the disease. |
| Clinical Indications |
Occupational exposure |
| Reference range | Plasma: <10 nmol/L Whole blood: 80-200 nmol/L |
| Sample & container required | Whole Blood: EDTA trace element free (royal blue top) preferred, standard EDTA (lavender top) acceptable. Urine: sterile universal or plain 24hr collection |
| Sample volume | 0.5 mL |
| Turnaround time | 2 weeks |