|Category||Biochemistry >> Trace elements|
Manganese is a trace element that is an essential co-factor for several enzymes, including manganese superoxide dismutase, pyruvate carboxylase and isocitrate dehydrogenase. Manganese is typically measured to assess risk of toxicity due to industrial exposure or over-supplementation of Mn in patients on TPN. The symptoms of toxicity are largely neurological and are similar to Parkinson’s disease. Patients with Behçet disease, a form of chronic systemic vasculitis, also exhibit increased blood manganese, and it is suggested that increased activity of superoxide dismutase may contribute to the pathogenesis of the disease.
Plasma: <10 nmol/L
Whole blood: 80-200 nmol/L
|Sample & container required||Whole Blood: EDTA trace element free (royal blue top) preferred, standard EDTA (lavender top) acceptable. Urine: sterile universal or plain 24hr collection|
|Sample volume||0.5 mL|
|Turnaround time||2 weeks|