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Paraneoplastic cerebellar degeneration (PCD) is a heterogeneous group of disorders characterised by subacute cerebellar ataxia, specific tumour types and (often) associated anti-neuronal antibodies (of which there have been 9 characterised.) Initial screen includes Yo and Ri; the following antibodies are available.
Purkinje cell cytoplasm and axons
Neuronal nuclei, perikaryon
Nuclei of both central and peripheral neurones
Nuclei of central neurones
Breast, SCLC, gynaecological
Central presynaptic terminals
Breast cancer, SCLC
Please include full clinical details to ensure the most appropriate antibodies are tested.
Sample & container required
RST (rust top), Gel SST (yellow top), Can also be performed on CSF
5 -10 mL (1 mL serum)
This test is currently unaccredited due to a recent change in platform.