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Neuronal antibodies

Category
Test background

Paraneoplastic cerebellar degeneration (PCD) is a heterogeneous group of disorders characterised by subacute cerebellar ataxia, specific tumour types and (often) associated anti-neuronal antibodies (of which there have been 9 characterised.) Initial screen includes Yo and Ri; the following antibodies are available.

Antibody Staining pattern Associated tumours
Yo (PCA-1) Purkinje cell cytoplasm and axons Ovary, breast
Ma (Ma1) Neuronal nuclei Various cancer
Ta (Ma2) Neuronal nuclei, perikaryon Testicular cancer
Hu (ANNA1) Nuclei of both central and peripheral neurones SCLC
Ri (ANNA2) Nuclei of central neurones Breast, SCLC, gynaecological
CV2/CRMP Oligodendrocytes cytoplasm SCLC, thymoma
Amphiphysin Central presynaptic terminals Breast cancer, SCLC
Clinicial Indications

Please include full clinical details to ensure the most appropriate antibodies are tested.

Reference range

Negative

Sample & container required RST (rust top), Gel SST (yellow top), Can also be performed on CSF
Sample volume 5 -10 mL (1 mL serum)
Turnaround time 14 days
Notes

This test is currently unaccredited due to a recent change in platform.