|Category||Biochemistry >> Trace elements|
Selenium is an essential trace element. It is known to be an important cofactor in a variety of biological processes including: thyroid hormone production, antioxidants, glutathione pathway, immune response and mitochondrial function. Deficiency manifests as both Keshan syndrome, a cardiomyopathy prevalent amongst children and women, and Kashin-Beck disease, which causes osteoarthropathy primarily afflicting children. These conditions typically arise in selenium-restricted diets, such as secondary to long-term parenteral nutrition, or deficiency due to the presence of an inborn error of metabolism. Selenium has a low threshold of toxicity, commencing at approximately 10 times the dietary requirement.
- Suspected selenium deficiency, ie. patient on restricted diet such as total parenteral nutrition
|Sample & container required||Serum: Trace element free (royal blue top) preferred, yellow top SST and red top serum accepted.|
|Sample volume||0.5 mL|
|Transport storage||Stable at 2-8°C. Sample can be sent by first class post.|
|Turnaround time||1 week|
Grossly haemolysed samples are unsuitable for this assay.