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Serological investigation of autoimmune haemolytic anaemia

Category Blood Transfusion
Test background

Autoimmune haemolytic anaemia (AIHA) is caused by autoantibody-induced haemolysis (the premature destruction of circulating red blood cells). Usually idiopathic, it is also associated with infection, lymphoproliferative disorders, autoimmune diseases, and some drugs.

Clinical Indications

Tests to determine the presence and specificity of a red cell autoantibody if AIHA is suspected.

Reference range

Negative (ie. no evidence of autoimmune haemolytic anaemia).

Sample & container required EDTA (lavender top)
Sample volume 2 x 6 mL
Turnaround time Dependent on clinical requirement. Contact the laboratory to discuss further.

If autoimmune haemolytic anaemia is suspected, discuss with a haematologist and/or the Blood Transfusion department to guide investigation.
May be referred to the NHS Blood and Transplant service for confirmation if necessary.