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Sex hormone binding globulin (SHBG)

Category Biochemistry >> Endocrinology
Test background

SHBG is a protein that is produced by the liver and binds tightly to the hormones testosterone, dihydrotestosterone (DHT) and oestradiol, and transports them in the blood in an inactive form. Low concentrations in women may correspond with higher free testosterone concentrations leading to virilisation, while high levels in men (and conversely low free testosterone) is associated with impaired fertility, libido and erectile dysfunction.

Clinical Indications

Hirsuitism in women
Fertility, erectile dysfunction and/or reduced libido in men

Reference range


Male 15-55 nmol/L
Female 30-100 nmol/L
Sample & container required Serum (red top)
Sample volume 1 mL
Turnaround time 1 week