|Category||Haematology >> Specialised Coagulation Services|
The thrombophilia screen includes the following: • coagulation screen • lupus anticoagulant • protein C • protein S • antithrombin assays • Factor V Leiden • Prothrombin gene mutation testing
• The predictive value of inherited thrombophilia screening in those who have a history of venous thromboembolism has been over-estimated in the past, and for family members of affected individuals. Likewise, the association between positive inherited thrombophilia tests and adverse pregnancy outcomes is somewhat controversial. Furthermore, inherited thrombophilia tests are a form of genetic testing. Discussion on an individual patient basis with Haematology may be appropriate in many cases.
See ‘Coagulation Screen’ for PT, APTT, Fibrinogen and TT reference ranges
See ‘Protein C/S’ or ‘Antithrombin Level’ for reference ranges
|Sample & container required||4 x 4.5 mL sodium citrate (pale blue top) adults
4 x 1.8 mL sodium citrate (pale blue top) paediatrics
Plus 1 x 4 mL EDTA (lavender top) adults
or 1 x 0.5 mL EDTA (lavender top) paediatrics
|Turnaround time||10-14 days|
Special handling: avoid prolonged stasis during venepuncture.