Total Procollagen 1 N-Terminal Propeptide (Total P1NP)
|Category||Biochemistry >> Bone Metabolism|
During the renewal of the skeleton, type 1 procollagen's amino- and carboxy-terminal regions are cleaved by specific proteases during its conversion to collagen and subsequent incorporation into bone matrix. The presence of these N-terminal extension propeptides, known as type 1 procollagen amino terminal peptides (P1NP), therefore reflects the deposition of collagen and can be defined as a marker of bone formation. P1NP is released into the blood stream during type 1 collagen formation. Elevated levels are found in patients with increased bone turnover. It is specifically used for monitoring of bone formation during anabolic therapy.
Assessing treatment response and compliance to osteoporosis therapy (such as bisphosphonates), but specifically the response to treatment by human PTH (Teriparatide).
Pre-menopausal women: 15.1-58.6 ng/mL.
|Sample & container required||SST (gold top). Samples can be stored at 4 ºC for up to 1 week, or at -20 ºC for longer storage (other non-accredited but acceptable sample types include, EDTA (lavender top) or heparin (green top) tubes).|
|Sample volume||250 µL|
|Transport storage||Stable at 2-8°C for 72 hours. Please freeze pending dispatch for analysis. Sample can be sent by first class post.|
|Turnaround time||4 weeks|
If monitoring the response to treatment, the sample should be collected at the same time of day.
Grossly haemolysed samples are unsuitable for this assay.