Total Procollagen 1 N-Terminal Propeptide (Total P1NP)
| Category | Biochemistry >> Bone Metabolism |
|---|---|
| Test background |
During the renewal of the skeleton, type 1 procollagen's amino- and carboxy-terminal regions are cleaved by specific proteases during its conversion to collagen and subsequent incorporation into bone matrix. The presence of these N-terminal extension propeptides, known as type 1 procollagen amino terminal peptides (P1NP), therefore reflects the deposition of collagen and can be defined as a marker of bone formation. P1NP is released into the blood stream during type 1 collagen formation. Elevated levels are found in patients with increased bone turnover. It is specifically used for monitoring of bone formation during anabolic therapy. |
| Clinical Indications |
Assessing treatment response and compliance to osteoporosis therapy (such as bisphosphonates), but specifically the response to treatment by human PTH (Teriparatide). |
| Reference range | Pre-menopausal women: 15.1-58.6 ng/mL. |
| Sample & container required | SST (gold top). Samples can be stored at 4 ºC for up to 1 week, or at -20 ºC for longer storage (other non-accredited but acceptable sample types include, EDTA (lavender top) or heparin (green top) tubes). |
| Sample volume | 250 µL |
| Transport storage | Stable at 2-8°C for 72 hours. Please freeze pending dispatch for analysis. Sample can be sent by first class post. |
| Turnaround time | 4 weeks |
| Notes | If monitoring the response to treatment, the sample should be collected at the same time of day. Grossly haemolysed samples are unsuitable for this assay. |