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Urinary steroid profile

Category Biochemistry
Test background

Requested for investigations of suspected steroid hormone-secreting tumours, causes of virilisation, ie. enzyme deficiencies that cause a masculine appearance, or in cases of apparent electrolyte imbalance with or without hypertension.

Clinical Indications

Diagnosis of CAH (cliteromegaly/ambiguous genitalia of infants or delayed puberty/deranged electrolyte balance in late-onset CAH) Diagnosis of adrenal hypofunction Suspected aldosterone resistance/insensitivity Diagnosis of adrenal tumours (common tumours secrete DHEAS, 11ß-hydroxyandrostenedione and pregnenolone)

Reference range

See report

Sample & container required 24 hour urine collection. Spot urine for babies/children
Sample volume 24 hour urine collection. 5 mL for babies/children
Turnaround time Up to 6 weeks

Not currently performed in house; this is a referred test.
Request should be made or sanctioned by a consultant endocrinologist.