Vitamin B12
Category | Biochemistry |
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Test background |
Megaloblastic anaemia is an anaemia (of macrocytic classification) which results from inhibition of DNA synthesis in red cell haematopoiesis. It is often due to deficiency of vitamin B12 and/or folic acid. Mild B12 deficiency is common in older persons, most often resulting from achlorhydria. Severe vitamin B12 hypovitaminosis can also result from a lack of intrinsic factor (autoimmune-mediated) causing pernicious anaemia as a consequence of B12 malabsorption. |
Clinical Indications |
Demonstrable macrocytic anaemia (as seen in red cell indices) Investigations of suspected subacute combined degeneration of the spinal cord (a deficiency not necessarily apparent in a patient's red cell indices) |
Reference range | 160-800 ng/L |
Sample & container required | SST (gold top) |
Sample volume | 0.5 mL |
Turnaround time | 1 day |