von Willebrand screen
| Category | Haematology >> Specialised Coagulation Services |
|---|---|
| Test background |
Von Willebrand disease (vWD) is the commonest inherited bleeding disorder, affecting up to 1 % of individuals, irrespective of gender or ethnicity. It comprises a number of types, all of which are characterised by a bleeding defect that resembles a platelet function defect, as platelet adhesion is impaired. The von Willebrand factor (vWF) also serves as a carrier protein for factor VIII and levels of factor VIII are often decreased when vWF levels are decreased. vWD is usually inherited as an autosomal dominant condition. |
| Clinical Indications |
Bleeding diathesis/hypocoagulopathy with presentations of epistaxis, menorrhagia and GI haemorrhaging Differential diagnosis of haemophilia and other forms of bleeding diathesis |
| Reference range | See Factor Assays for the Factor VIII reference ranges and Collagen Binding assay for appropriate range also. Please click on the table to view in more detail.
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| Sample & container required | 3 x 2.7 mL sodium citrate (pale blue top) adults; 3 x 1.8 mL sodium citrate (pale blue top) paediatrics |
| Turnaround time | 14 days |
| Notes | Special handling: avoid prolonged stasis during venepuncture. Sample must be received by lab within 4 hours of collection. Please note: samples will be rejected if underfilled or overfilled. Adult Reference Range: Data sourced via Stago from: Paediatric Reference Range Note: Due to the complexity of collecting blood samples for analysis on normal neonates and paediatric patients, the reference ranges for use on patients up to 16 years of age have been taken from published data, from a research study using comparable methodology and equipment as that currently employed in our organisation. Please contact the laboratory for coagulation paediatric ranges. Data sourced via Stago from: |
