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Xanthochromia (CSF spectrophotometry)

Category Biochemistry
Test background

A subarachnoid haemorrhage (SAH) is bleeding into the subarachnoid space surrounding the brain. It may arise spontaneously or due to trauma and is a medical emergency which can lead to death or severe disability, even if recognised and treated in an early stage. Haemoglobin from blood in CSF converts to bilirubin after 12 hours, and spectrophotometric measurement of bilirubin can confirm a suspected SAH.

Clinical Indications

Suspected subarachnoid haemorrhage.

Reference range

See report

Sample & container required CSF in universal container; Protect from light and rush to laboratory; Samples for Xanthochromia measurement must be delivered to the lab by hand; Transporting the sample by pod (PTS) could degrade the sample and give a false result
Sample volume 0.5 mL
Turnaround time 2 days